The Cooley Lab works to provide a strong and supportive environment for training at all levels.
Dissertation Research: We welcome graduate students interested in doing a rotation in the lab.
Postdoctoral Training: Postdocs interested in developing an independent research program using Drosophila oogenesis are welcome to apply. Must be willing to apply for fellowship support.
Undergraduate Research: The lab hosts Yale College students for research during the academic year and summer months.
Internships: Opportunities for summer research for high school students or undergraduates are available.
Here are a few ideas for rotation projects that have emerged from recent work in the lab:
·Live imaging of cytokinesis during Drosophila sperm development using fluorescent proteins and swept-field microscopy to study previously unknown intermediates of ring canal formation.
·Analyze Focused Ion Beam Scanning Electron Microscopy (FIB SEM) data of wild type and mutant testes to extract high-resolution 3-D information for the transformation to ring canals.
·Localized biotinylation to identify proteins at the RC/plasma membrane interface. Use APEX-tagged, membrane proximal proteins to biotinylate neighboring proteins.
·Generate and analyze dual fluorescent protein reporters to directly visualize tissue-specific stop codon readthrough in vivo.
·Determine the function of carboxy terminal extensions by analyzing CRISPR-mediated deletions of ORF2 in Drosophila genes.
·Investigate the mechanism of stop codon readthrough with a candidate gene shRNA screen.
Please contact Lynn Cooley for more information, or to make an appointment to talk about an ongoing or new project.